Combined use of clozapine and cariprazine in treatment-resistant schizophrenia, is it a good choice?
Introduction Treatment-resistant schizophrenia (TRS) affects 30% of people with a diagnosis of schizophrenia, and is defined as nonresponse to at least two trials of antipsychotic medication of adequate dose and duration.Clozapine is the only evidence-based treatment for TRS.Cariprazine may be considered significantly more efficacious than risperid